AS OLD LONDON

Brand	Owner	Address	Description
OLD LONDON	CHIPITA AMERICA, INC.	ONE WESTBROOK CORPORATE CENTER SUITE 640 WESTCHESTER IL 60154	as to words Old London Feb. 1958;[ Ready-to-Eat Popcorn,] Melba Toast[ , Empty Ice Cream Cones, Sandwiches Consisting of Two Baked Waffle Type Wafers Separated by a Spread of Cheese, Spread of Peanut-Butter, Pizza Flavored Filling or Salami Flavored Filling, Corn Chips, Cheese Flavored Corn Snacks and Cheese Flavored Crackers ];
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzhe## disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer's disease, based on expression of all three forms of the ?-amyloid precursor protein (APP), APP695, APP751, and APP770, as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer's disease (FAD) mutations at amino acid 717, predicted mutations in the APP gene, and truncated forms of APP that contain the A? region. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation. The transgenic animals, or animal cells, are used to screen for compounds altering the pathological course of Alzheimer's disease as measured by their effect on the amount of APP, ?-amyloid peptide, and numerous other Alzheimer's disease markers in the animals, the neuropathology of the animals, as well as by behavioral alterations in the animals.