DIAGNOSTIC IMAGING AGENTS ULTRASOUND

Brand	Owner (click to sort)	Address	Description
DEF(INITY)	LANTHEUS MEDICAL IMAGING, INC.	331 Treble Cove Road North Billerica MA 01862	Diagnostic imaging agents and ultrasound contrast agents having high resolution echo characteristics for ultrasound imaging; diagnostic imaging agents for use in ultrasound imaging; ultrasound contrast agents in the nature of microbubbles being contrast media for diagnostic imaging and therapy; therapeutic delivery agents in the form of microbubbles that facilitate the delivery of pharmaceutical preparations for human use; therapeutic agents in the nature of microbubbles being contrast media for medical use;
HIGH DEF(INITY)	LANTHEUS MEDICAL IMAGING, INC.	331 Treble Cove Road North Billerica MA 01862	Diagnostic imaging agents and ultrasound contrast agents having high resolution echo characteristics for ultrasound imaging; diagnostic imaging agents for use in ultrasound imaging; ultrasound contrast agents in the nature of microbubbles being contrast media for diagnostic imaging and therapy; therapeutic delivery agents in the form of microbubbles that facilitate the delivery of pharmaceutical preparations for human use; therapeutic agents in the nature of microbubbles being contrast media for medical use;
MBI	Molecular Biosystems, Inc.	Suite A 11180 Roselle St. San Diego CA 92121	diagnostic imaging agents for ultrasound, magnetic resonance and CT imaging;
MOLECULAR BIOSYSTEMS	Molecular Biosystems, Inc.	Suite A 11180 Roselle St. San Diego CA 92121	diagnostic imaging agents for ultrasound, magnetic resonance and CT imaging;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.