HUMAN ENGINEERING APPLIED TECHNOLOGY

Brand	Owner	Address	Description
USER TECH	KIM, YONG K.	950 N. Glebe Road Arlington VA 22203	human engineering and applied technology in system research, system design and development, and life cycle support required to implement solutions to data processing problems and to develop and improve data processing systems;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an ?-galactosyl (Gal) epitope, for example, Gal?(1->3)Gal?(1->4)GlcNac (linear B type 2) or Gal?(1->3) Gal?(1->4)Glc (linear B type 6). The second is an N-glycolylneuraminic acid (NeuGc) structure. By eliminating these epitopes, preferably by genetically engineering the animal so that the epitope is either not produced or is greatly reduced, or by chemical or enzymatic treatment of the animal's cells to remove the epitopes, it is possible to produce organs, tissues and cells suitable for xenotransplantation into humans. Cells can be rendered even more compatible by genetically engineering the animal to express a human complement regulatory protein (inhibitor), such as CD59, on its cells, or to express an excess of a pig complement regulatory protein.