IMMUNODIAGNOSTIC ASSAY TEST KITS CONSISTING

Brand Owner Address Description
BIOSTAR THERMO BIOSTAR INC. 331 SOUTH 104TH STREET LOUISVILLE CO 80027 immunodiagnostic assay test kits consisting primarily of reagents and other chemicals which detect immune complexes in body fluids for scientific or research use;
 

Where the owner name is not linked, that owner no longer owns the brand

    
Technical Examples
  1. A method for in vitro screening a group of test substances for a ligand using two assay systems, i.e. a cellular or tissue assay system and an enzymatic assay system, is described. First, those test substances are selected which have transcriptional ER-mediated activity measured by an ER-driven reporter gene in the cellular or tissue assay system with an EC50(ER)(half-maximally effective ligand concentration) lower than or equal to 10 nmol/l. Then in an enzymatic assay system the selected test substances having the required transcriptional ER-mediated activity are tested by measuring a physical-chemical interaction (recruitment) of SRC-1 and the ER in the presence of the test substances. The selected ligand activates the ER and induces interaction with the co-present SRC-1 with an E50(ER+SRC) higher than or equal to 100 nmol/l. The ligands found by the inventive screening method are useful for treatment and prevention of neuro-degeneration in the cerebral cortex, especially of age-related cognitive disorders, affective disorders, Alzheimer's diseases and cerebral ischemia/stroke.