NEURO ASSAY

Brand Owner Address Description
NEUROASSAY Renovis, Inc. 270 Littlefield Avenue South San Francisco CA 94080 NEURO ASSAY;Pharmaceutical, medical, scientific, veterinary, agricultural, and product research and development services for third parties; pharmaceutical, medical, scientific, veterinary, agricultural and product development consulting services to third parties;
 

Where the owner name is not linked, that owner no longer owns the brand

    
Technical Examples
  1. A method for in vitro screening a group of test substances for a ligand using two assay systems, i.e. a cellular or tissue assay system and an enzymatic assay system, is described. First, those test substances are selected which have transcriptional ER-mediated activity measured by an ER-driven reporter gene in the cellular or tissue assay system with an EC50(ER)(half-maximally effective ligand concentration) lower than or equal to 10 nmol/l. Then in an enzymatic assay system the selected test substances having the required transcriptional ER-mediated activity are tested by measuring a physical-chemical interaction (recruitment) of SRC-1 and the ER in the presence of the test substances. The selected ligand activates the ER and induces interaction with the co-present SRC-1 with an E50(ER+SRC) higher than or equal to 100 nmol/l. The ligands found by the inventive screening method are useful for treatment and prevention of neuro-degeneration in the cerebral cortex, especially of age-related cognitive disorders, affective disorders, Alzheimer's diseases and cerebral ischemia/stroke.