POLYPEPTIDE PREPARATION FOR INHIBITION

Brand	Owner	Address	Description
THROMSTOP	BIOMEDICA DIAGNOSTICS INC.	94 WENTWORTH ROAD, PO BOX 1030 WINDSOR B0N 2T0 Canada	POLYPEPTIDE PREPARATION FOR THE INHIBITION OF THROMBIN IN BLOOD AND BLOOD COMPONENTS FOR DIAGNOSIS AND/OR PRESERVATION OF THE BLOOD OR BLOOD COMPONENT;THROMBIN STOP;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.