PRODUCT SCALE SYNTHESIZER OLIGONUCLEOTIDE

Brand	Owner	Address	Description
OLIGOPROCESS	CYTIVA SWEDEN AB	Björkgatan 30 Uppsala SE-75184 Sweden	Product scale synthesizer for oligonucleotide synthesis for therapeutic use;OLIGO PROCESS;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides. The acetonitrile may be removed from the solid support by one or both of drying and by washing with solvents. Preferred washing solvents comprise trialkylamines.