RENAL SHEAR

Brand	Owner	Address	Description
RENALSHEAR	HemoShear	2525 Cedar Ridge Lane Charlottesville VA 22901	RENAL SHEAR;testing services, namely, testing of the effects of pharmaceutical compounds and industrial chemicals on human surrogate cell culture models of the kidney and related organs; testing services, namely, testing for the efficacy, safety and toxicity of therapeutic compounds and industrial chemicals;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a-hydroxylase which can be used to generate the active form of vitamin D: 1,25-diOH vitamin D3. The fibroblast cultures and co-culture of renal cortical cells express the gene for erythropoietin and secrete erythropoietin into the culture supernatant. Other shear stress response genes are also modulated by shear stress, such as toxin receptors megalin and cubulin (gp280). Also provided is a method of treating in-need individual with the functional proteins produced in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel.