Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity

Patent Number: 9387200

Patent Date: 2016-07-12

Patent type: utility

The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).

Inventors

First Name Last Name City State Country
Lee A. Flippin - - -
Michael P. Arend - - -
Min Wu - - -
Xiaoti Zhou - - -

IPCs

Section Class Sub Class Group Sub Group
A 61 K 31 437
C 07 D 513 04
A 61 K 31 497
A 61 K 45 06

Assignee

Organization First Name Last Name City State Country
FibroGen, Inc. - - - - -