Sock for treatment of foot and leg wounds, methods of use and manufacture

A tubular body is configured to be disposed around and to apply compression to an extremity. The tubular body includes a treatment area having a first filament and a second filament. Both the first filament and the second filament are disposed to engage the surface of the extremity. The first filament includes AgNP in a concentration effective to promote healing of a wound on the surface of the extremity. The second filament includes a metal having a composition that forms a galvanic couple with silver. The first filament and the second filament are arranged in the tubular body such that the AgNP and metal form galvanic couples across at least a portion of the treatment area when in the presence of a fluid in the wound of the extremity that produce an electric current in an amount effective to further promote healing of the wound.